Alectryon can generate cache files to memoize Coq's output, yielding faster compilation when Coq fragments embedded in a document have not changed:
alectryon --cache-directory _output/ --cache-compression=xz caching.v # Coq+reST → HTML, cached to _output/caching.v.cache; produces ‘caching.html’
(The --cache-compression flag is option; the default is to not compress caches.)